nagendra | National Institute of Science Education and Research

Nagendra K. Sharma

Associate Professor

Chemical Sciences

nagendra@niser.ac.in

Personal Page

Education

2006-2009 Post. Doc.- Department of Chemistry, University of Utah, Salt Lake City, Utah (USA) (Mentor: Prof. Dale C. Poulter)

2000-2006 Ph.D.- Organic Chemistry Synthesis (OCS), National Chemical Laboratory (NCL)- Pune & (University of Pune)- Maharashtra (Mentor: Prof. K. N. Ganesh)

1999 M.Sc (Spl. Organic Chemistry).- Delhi Unversity, Delhi

1997 B.Sc (Honours): Delhi Unversity, Delhi

Teaching

A. Core courses (M.Sc./Ph.D.)

C501 Organic Chemistry-III (Natural product/Heterocycles/Biomolecules)
C341 Organic Chemistry Lab I
C344 Organic Chemistry Lab II
C565 Advanced Organic Chemistry
C344 Organic Chemistry Lab II
C244 Biomolecular Chemistry Lab
C344 Organic Chemistry Lab II
C301 Physical Organic Chemistry
C344 Organic Chemistry Lab II
C403 Chemistry of Heterocycles and Natural products
C204 Reagents in Organic Syntheses
C203, Reaction Mechanism in Organic Chemistry

B. Elective courses (M.Sc/Ph.D.).

C565 (4) Advanced Organic Chemistry
C561 (4) Advanced Bio-organic Chemistry

Publications

Fluorescent DNA Analog: 2-Aminotroponyl-Pyrrolyl-2’-Deoxyuridinyl DNA Oligo Enhance Fluorescence in DNA-duplex as compared to 2-Aminotroponyl-Ethynyl-2’-Deoxyuridinyl DNA Oligo. Bollu, A.; Panda, S. S.; Sharma, N. K. 2022, (https://doi.org/10.1080/15257770.2022.2111442; Accepted)
Nonbenzenoid BODIPY Analogues: Synthesis, Structural Organization, Photophysical Studies, and Cell Internalization of Biocompatible N-Alkyl-Aminotroponyl Difluoroboron (Alkyl-ATB) Complexes, Palai, B. B.; Kumari, S.; Dixit, M.; and Sharma, N. K.* ACS Omega, 2022 (Accepted)
Novel Cinnamic Acid Analogues: Synthesis of Aminotroponyl Acrylates by Pd(II)-Catalysed C(sp2)-H Olefination, Jena, C. K.; Sharma, N. K. Chem. Commun. 2022, 58, 8077-8080
4-Aminopyrazolonyl Amino Acid Comprising Tri-Peptides Forms Organogel With Co-Solvent (EtOAc:Hexane), Bollu, A.; Giri, P.; Dalabehera, N. R.; Asmi, A. R.; Sharma, N. K. Frontiers in Chemistry, 2022, 10, 821971(10.3389/fchem.2022.821971)
Syntheses and Structural Analyses of Ethylenediprolyl Peptides and Their Metal Complexes with Cu(II) Ion. Gupta, M. K.; Jena, C. K.;
Balachandra, C.; Sharma, N. K. J. Org. Chem, 2021, 86, 16327–16336.
Pd-Catalyzed C(sp2)-H Olefination: Synthesis of N-alkylated Isoindolinone Scaffolds from Arylamide of Amino acid esters.
Gupta, M. K.; Jena, C. K.; Sharma, N. K. Org. Biomol. Chem. 2021, 19, 10097-10104.
N-Arylated peptide: troponyl residue influences the structure and conformation of N-troponylated-(di/tri)-peptides; Palai, B. B.; Sharma, N. K.* CrystEngComm, 2021, 23, 131-139.
The 2’-caged-tethered-siRNA Shows Light-Dependent Temporal Controlled RNAi activity for GFP gene into HEK293T cells; Bollu, A., Hassan, M. K, Dixit, M. Sharma, N. Bioorg. Med. Chem. 2020, (Accepted; DOI: 10.1016/j.bmc.2020.115932)
Instability of Amide Bond With TFA (20%): Synthesis, Conformational Analysis and Mechanistic Insights of Cleavable Amide Bond Comprising β-Troponylhydrazino Acid; N. Dalabehera, N.; Meher, S; Palai, B. B.; Sharma, N. K.* ACS Omega, 2020, 5, 26141–26152.
Biased Photo Cleavage of N1-/N6-Nitrobenzyl from 2’-hydroxyethyl-Adenosine and their DNA/RNA Caged-Analogues, Bollu, A. Sharma, N. K. J. Photochem. Photobiol. Chem-A, 2021, 440, 112864.
Synthesis and biochemical evaluation of Aminopropanolyl-Thymine tri-Phosphate (ap-TTP), Gade, C. R. and Sharma, N. K., Nucleosides, Nucleotides, and Nucleic Acid. 2020, 39, 730-743.
BODIPY Analogues: Synthesis and Photophysical studies of difluoro Boron complexes from 2-Aminotropone Scaffolds through N,O-Chelation, Palai, B. B.; Soren, R.; Sharma, N. K.* Org. Biomol. Chem., 2019, 17, 6497-6505.
Syntheses of β3-Aryl-Alaninyl Derivatives by sp3 C-H Activation with Pd(OAc)2 Catalyst/Pivalic Acid in DCE and Their Structural Studies in Solid State, Mohanlal, S. Sharma, N. K.* Chem. Select, 2019, 4, 7058-7066
Cleavable Amide Bond: Mechanistic Insight of Cleavable 4-Aminopyrazolyloxy Acetamide at low pH, Bollu, A. Sharma, N. K.* J. Org. Chem. 2019, 84, 5596–5602.
Tropolone conjugated DNA: pH Induced Fluorescence Enhancement of Tropolone in DNA Duplex, Bollu, A. Sharma, N. K., ChemBioChem 2019, 20, 1-10.
Syntheses and Conformational Analysis of New Aminopyrazolonyl Amino Acid (APA)/Peptides, Bollu, A. Sharma, N. K. Eur. J. Org. Chem. 2019, 1286-1292.
Helical supramolecular self-assembly by prolamide thymidine/uridine analogues Gade, C. R.; Sharma, N. K.* Supramolecular Chemistry, 2018, 30, 965-969
Direct/Reversible Amidation of Troponyl Alkylglycinates via Cationic Troponyl Lactones and Mechanistic Insights, Balachandra, C.; Sharma, N. K.* ACS Omega, 2018, 3 , 997–1013
Hybrid DNA i-motif: Aminoethylprolyl-PNA (pC5) enhance the stability of DNA (dC5) i-motif structure Gade, C. R.; Sharma, N. K..* Bioorg. Med. Chem. Lett. 2017, 17, 5424-5428
Novel fluorophores: Syntheses and photophysical studies of Boron-aminotroponimines. Balachandra, C.; Sharma, N. K.* Dyes and Pigments, 2017, 137, 532-538.
Dideoxy Nucleoside Triphosphate (ddNTP) Analogues:Synthesis and Polymerase Substrate Activities of Pyrrolidinyl Nucleoside Triphosphates (prNTPs): Gade, C. R.; Dixit, M.; Sharma, NK.* Bioorg. Med. Chem. 2016, 24, 4016-4022.
Instability of Amide Bond Comprising the 2-Aminotropone Moiety: Cleavable under Mild Acidic Conditions. Balachandra C, Sharma N. K* Org. Lett. 2015, 17, 3948−3951. DOI: 10.1021/acs.orglett.5b01535.
Methylene Salicylicacidyl Hexamer (MSH) Has DNAse Activity. Tiwari A, Gade CR, Dixit M, Sharma NK*. Appl Biochem Biotechnol. 2015 , 176, 1791-800. DOI: 10.1007/s12010-015-1678-z.
Synthesis and spectroscopic studies of berberine immobilized modified cellulose material. Gade CR, Sharma NK* RSC Adv. 2014 , 4, 39337-39342. DOI: 10.1039/C4RA06015F
Synthesis and conformational analysis of new troponyl aromatic amino acid. Balachandra C, SharmaNK*. Tetrahedron 2014, 70, 7464–7469. DOI: 10.1016/j.tet.2014.08.014
Binding Studies of Natural Product Berberine with DNA G-Quadruplex. Sharma NK*, Lunawat P, Dixit M, Am. J. Biochem. Biotechnol. 2011, 7, 130-134. DOI : 10.3844/ajbbsp.2011.130.134
Enhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone. Sharma NK*, Ganesh KN. Org Biomol Chem. 2011, 9, 725-9. DOI: 10.1039/c0ob00528b
Base dependent pyrrolidine ring pucker in aep-PNA monomers: NMR and PSEUROT analysis. Tetrahedron 2010, 66, 9165-9170. DOI: 10.1016/j.tet.2010.09.082
Type II isopentenyl diphosphate isomerase: probing the mechanism with alkyne/allene diphosphate substrate analogues. Sharma N. K., Pan J. J, Poulter CD*. Biochemistry. 2010, 49, 6228-33. DOI: 10.1021/bi100844e.
PNA C-C+ i-motif: superior stability of PNA TC8 tetraplexes compared to DNA TC8 tetraplexes at low pH. Sharma NK, Ganesh KN*. Chem Commun (Camb). 2005, 34, 4330-2.DOI: 10.1039/506870C
Regioselective oxidation of N-alkylpyrrolidines to pyrrolidin-5-ones by RuCl3/NaIO4. Sharma NK, Ganesh KN* Tetrahedron Lett. 2004, 45, 1403–1406. DOI: 10.1016/j.tetlet.2003.12.072
Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA). Sharma NK, Ganesh KN*. Chem Commun (Camb).2003, 19, 2484-5. DOI: 10.1039/B307362A

Specialisation

Organic Chemistry Synthesis: (Peptide Chemistry and Nucleic Acid Chemistry)

Research

Synthesis of Functional DNA Comprising Aminotropnyl 2’-deoxyuridine Analogues For Cross-linking with Peptides (SERB-CRG/2020/001028), Continue..
CRISPR-RNACas9 System: Syntheses and Biochemical Evaluations of Nucleobase Modified Tropolonyl Ribose Nucleoside in CRISPR-RNA (DBT-BT/PR26143/GET/119/112/2017), Continue..
Syntheses and biochemical evaluation of dNTP/ddNTP analogues (Funded By SERB-DST); Completed
Syntheses of mi/si-RNA analogue for RNAi studies (Funded by DBT); Completed
Synthesis and Biophysical studies of PNA/DNA-teraplexation (G-Quartet/i-motif) (Funded by CSIR-HRDG); Completed

Group Members

Current Group Members

Postdoctoral Fellow

Dr. Smitha Mohanlal

Dr. Supriya Kumari

Dr. Raghunath Bag

RA (SPA)

Dr. Bibhuti B. Palai

Ph. D. Students

1. Bibhuti Bhusana Palai

2. Sagarika Meher

3. Manish Kumar Gupta

4. Chinmay Kumar Jena

5. Subhashree S. Panda

6. Ankita Panda

Integ-M. Sc. Project Students

1. Diprupa Saha

2. Adesh N. Thawale

3. Subhasish Panda

4. Sangita Mandal

5. Pritha Gayen

6. Abhinandan Mohanty

7. Maria Tomy

PhD Completed

1. Dr. Chenikkayala Balachandra

2. Dr. Chandrasekhar Reddy Gade

3. Dr. Amarnath Bollu

4. Dr. Bibhuti Bhusana Palai

Former Postdocs & Integ-M.Sc Students

1. Rewati Raman Ujjwa (M. Sc)

2. Saikat Nandi (M. Sc.)

3. Dr. Sujitlal Bhakta (Postdoctoral Fellow)

3. Nihar Ranjan Dalabehera (M.Sc.)

4. Ramachandra Soren (M.Sc.)

5. Saideep (M.Sc.)

6. Prajnanandan Giri (M. Sc.)

7. Rohit Kumar (M. Sc.)

8. Tushar Kant Patra (M.Sc.)

9. Shiba Prasad Jena (M.Sc.)

10. Gajendra Marandi (M.Sc.)

11. Anil Kumar Haiburu (M.Sc.)

12. Asmita Rani Asmi (M.Sc)

Recent Activities

As convener, organize a national conference NBCC-2018 at NISER

NATIONAL BIOORGANIC CHEMISTRY CONFERENCE , NISER Bhubaneswar (https://www.niser.ac.in/nbcc/)

Picture for NBCC-2018: https://drive.google.com/drive/folders/1B06Bz-2RYpd0aYQ0SznlVfERLl3llOpJ

Responsibilities

a. ESI-Mass Incharge

b. CD-incharge

c. PGCS-SCS (2016-2018)

d. FIC-Transport

Contacts

Associate Professor, School of Chemical Sciences,

National Institute of Science Education and Research(NISER)-Bhubaneswar

Bhimpur-Padanpur

Jatni-752050, Odisha (India), Tel. 0674-249-4141/68

E-Mail: nagendra@niser.ac.in; http://www.niser.ac.in

Phone No.

0674-249-4141

Extension

2141

Room No.

315

NISER

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