Main profile

Nagendra K. Sharma

School: 

Chemical Sciences

Designation: 

Associate Professor

Education: 

2006-2009 Post. Doc.- Department of Chemistry, University of Utah, Salt Lake City, Utah (USA) (Mentor: Prof. Dale C. Poulter)

2000-2006 Ph.D.- Organic Chemistry Synthesis (OCS),  National Chemical Laboratory (NCL)- Pune & (University of Pune)- Maharashtra (Mentor: Prof. K. N. Ganesh)

1999 M.Sc (Spl. Organic Chemistry).- Delhi Unversity, Delhi

1997 B.Sc (Honours): Delhi Unversity, Delhi

 

Specialisation: 

Organic Syntheses

Bioorganic Chemistry

 

Publications: 

1. The 2’-caged-tethered-siRNA Shows Light-Dependent Temporal Controlled RNAi activity for GFP gene into HEK293T cells; Bollu, A., Hassan, M. K, Dixit, M. Sharma, N. Bioorg. Med. Chem. 2020, (Accepted; DOI: 10.1016/j.bmc.2020.115932)

2. N-Arylated peptide: troponyl residue influences the structure and conformation of N-troponylated-(di/tri)-peptides; Palai, B. B.; Sharma, N. K.* CrystEngComm, 2020 (Accepted; DOI: 10.1039/D0CE01386B).

3. Instability of Amide Bond With TFA (20%): Synthesis, Conformational Analysis and Mechanistic Insights of Cleavable Amide Bond Comprising β-Troponylhydrazino Acid; N. Dalabehera, N.; Meher, S; Palai, B. B.; Sharma, N. K.* ACS Omega, 2020, 5, 26141–26152.

4. Biased Photo Cleavage of N1-/N6-Nitrobenzyl from 2’-hydroxyethyl-Adenosine and their DNA/RNA Caged-Analogues, Bollu, A. Sharma, N. K. Journal of Photochemistry and Photobiology A: Chemistry, 2021, 440, 112864.

5. Synthesis and biochemical evaluation of Aminopropanolyl-Thymine tri-Phosphate (ap-TTP),  Gade, C. R. and Sharma, N. K., Nucleosides, Nucleotides, and Nucleic Acid. 2020, 39, 730-743.

6. BODIPY Analogues: Synthesis and Photophysical studies of difluoro Boron complexes from 2-Aminotropone Scaffolds through N,O-Chelation, Palai, B. B.; Soren, R.; Sharma, N. K.* Org. Biomol. Chem., 2019, 17, 6497-6505.

7. Syntheses of β3-Aryl-Alaninyl Derivatives by sp3 C-H Activation with Pd(OAc)2 Catalyst/Pivalic Acid in DCE and Their Structural Studies in Solid State, Mohanlal, S. Sharma, N. K.* Chem. Select, 2019, 4, 7058-7066

8. Cleavable Amide Bond: Mechanistic Insight of Cleavable 4-Aminopyrazolyloxy Acetamide at low pH, Bollu, A. Sharma, N. K.* J. Org. Chem. 2019, 84, 5596–5602.

9. Tropolone conjugated DNA: pH Induced Fluorescence Enhancement of Tropolone in DNA Duplex, Bollu, A. Sharma, N. K., ChemBioChem 2019, 20, 1-10. 

10. Syntheses and Conformational Analysis of New Aminopyrazolonyl Amino Acid (APA)/Peptides, Bollu, A. Sharma, N. K. Eur. J. Org. Chem. 2019, 1286-1292. 

11. Helical supramolecular self-assembly by prolamide thymidine/uridine analogues Gade, C. R.; Sharma, N. K.*  Supramolecular Chemistry, 2018, 30, 965-969  

12. Direct/Reversible Amidation of Troponyl Alkylglycinates via Cationic Troponyl Lactones and Mechanistic Insights,  Balachandra, C.; Sharma, N. K.* ACS Omega, 2018, 3 , 997–1013

13. Hybrid DNA i-motif: Aminoethylprolyl-PNA (pC5) enhance the stability of DNA (dC5) i-motif structure Gade, C. R.; Sharma, N. K..* Bioorg. Med. Chem. Lett. 2017, 17, 5424-5428

14. Novel fluorophores: Syntheses and photophysical studies of Boron-aminotroponimines. Balachandra, C.; Sharma, N. K.* Dyes and Pigments, 2017, 137, 532-538.

15. Dideoxy Nucleoside Triphosphate (ddNTP) Analogues:Synthesis and Polymerase Substrate Activities of Pyrrolidinyl Nucleoside Triphosphates (prNTPs): Gade, C. R.; Dixit, M.; Sharma, NK.* Bioorg. Med. Chem. 2016, 24, 4016-4022.

16. Instability of Amide Bond Comprising the 2-Aminotropone Moiety: Cleavable under Mild Acidic Conditions. Balachandra C, Sharma N. K* Org. Lett. 2015, 17, 3948−3951. DOI: 10.1021/acs.orglett.5b01535.
17. Methylene Salicylicacidyl Hexamer (MSH) Has DNAse Activity. Tiwari A, Gade CR, Dixit M, Sharma NK*. Appl Biochem Biotechnol. 2015 , 176, 1791-800. DOI: 10.1007/s12010-015-1678-z.
18. Synthesis and spectroscopic studies of berberine immobilized modified cellulose material. Gade CR, Sharma NK* RSC Adv. 2014 , 4, 39337-39342. DOI: 10.1039/C4RA06015F
19. Synthesis and conformational analysis of new troponyl aromatic amino acid. Balachandra C, SharmaNK*. Tetrahedron 2014, 70, 7464–7469. DOI: 10.1016/j.tet.2014.08.014
20. Binding Studies of Natural Product Berberine with DNA G-Quadruplex. Sharma NK*, Lunawat P, Dixit M, Am. J. Biochem. Biotechnol. 2011, 7, 130-134. DOI : 10.3844/ajbbsp.2011.130.134
21. Enhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone. Sharma NK*, Ganesh KN. Org Biomol Chem. 2011, 9, 725-9. DOI: 10.1039/c0ob00528b
22. Base dependent pyrrolidine ring pucker in aep-PNA monomers: NMR and PSEUROT analysis. Tetrahedron 2010, 66, 9165-9170. DOI: 10.1016/j.tet.2010.09.082
23. Type II isopentenyl diphosphate isomerase: probing the mechanism with alkyne/allene diphosphate substrate analogues. Sharma N. K., Pan J. J, Poulter CD*. Biochemistry. 2010, 49, 6228-33.   DOI: 10.1021/bi100844e.
24. PNA C-C+ i-motif: superior stability of PNA TC8 tetraplexes compared to DNA TC8 tetraplexes at low pH. Sharma NK, Ganesh KN*. Chem Commun (Camb). 2005, 34, 4330-2.DOI: 10.1039/506870C
25. Regioselective oxidation of N-alkylpyrrolidines to pyrrolidin-5-ones by RuCl₃/NaIO4. Sharma NK, Ganesh KN* Tetrahedron Lett. 2004, 45, 1403–1406. DOI: 10.1016/j.tetlet.2003.12.072  
26. Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA).  Sharma NK, Ganesh KN*. Chem Commun (Camb).2003, 19, 2484-5. DOI: 10.1039/B307362A

 

Recent Activities: 

As convener, organize a national conference NBCC-2018 at NISER

NATIONAL BIOORGANIC CHEMISTRY CONFERENCE , NISER Bhubaneswar (https://www.niser.ac.in/nbcc/)

Picture for NBCC-2018: https://drive.google.com/drive/folders/1B06Bz-2RYpd0aYQ0SznlVfERLl3llOpJ

 

 

 

Responsibilities: 

a. ESI-Mass Incharge

b. CD-incharge

c. PGCS-SCS (2016-2018)

Research: 

1. CRISPR-RNACas9 System: Syntheses and Biochemical Evaluations of Nucleobase Modified Tropolonyl Ribose Nucleoside in CRISPR-RNA (Funded by DBT)

2. Syntheses and biochemical evaluation of dNTP/ddNTP analogues (Funded By SERB-DST)

3. Syntheses of mi/si-RNA analogue for RNAi studies (Funded by DBT)

4. Synthesis and Biophysical studies of PNA/DNA-teraplexation (G-Quartet/i-motif) (Funded by CSIR-HRDG)

5. Synthesis of unnatural peptidomimics

6. Synthesis and mechanistic studies of substarte/inhibitors for IPPisomerase enzyme of isoprenoid pathways

Teaching: 

A. Core courses (M.Sc./Ph.D.)

1. C501 Organic Chemistry-III (Natural product/Heterocycles/Biomolecules)

2. C341 Organic Chemistry Lab I     

3. C344 Organic Chemistry Lab II

4. C565 Advanced Organic Chemistry

5. C344 Organic Chemistry Lab II

6. C244 Biomolecular Chemistry Lab

7. C344 Organic Chemistry Lab II

8. C301 Physical Organic Chemistry

9. C344 Organic Chemistry Lab II

10. C403 Chemistry of Heterocycles and Natural products

11. C204 Reagents in Organic Syntheses

12. C203, Reaction Mechanism in Organic Chemistry

B. Elective courses (M.Sc/Ph.D.).

1. C565 (4) Advanced Organic Chemistry

2. C561 (4) Advanced Bio-organic Chemistry

Contacts: 

Reader-F, School of Chemical Sciences,

National Institute of Science Education and Research(NISER)-Bhubaneswar

Bhimpur-Padanpur

Jatni-752050, Odisha (India), Tel. 0674-249-4141/68

E-Mail: nagendra@niser.ac.in; http://www.niser.ac.in

Phone No.: 

+91-674-249-4141/68

Extension: 

2141

Room No.: 

315

Mail ID: 

nagendra@niser.ac.in

Personal Page: 

My Homepage

Group Members: 

Research Associate

Current Ph. D. Persuing Students

1. Bibhuti Bhusana Palai

2. Sagarika Meher

3. Manish Kumar Gupta

4. Chinmay Kumar Jena

5. Subhashree S. Panda

M. Sc. Project Students

1. Shiba Prasad Jena

2. Gajendra Marandi

3. Anil Kumar Haiburu

4. Asmita Rani Asmi

PhD Completed 

1. Dr. Chenikkayala Balachandra

2. Dr. Chandrasekhar Reddy Gade

3. Dr. Amarnath Bollu

Former Students 

1. Dr. Smitha Mohanlal (Postdoctoral Fellow/CSIR-RA)

2. Dr. Sujitlal Bhakta (Short term Postdoctoral Fellow)

3. Nihar Ranjan Dalabehera 

4. Ramachandra Soren 

5. Saideep

6. Prajnanandan Giri

7. Rohit Kumar

8. Tushar Kant Patra

9. Saikat Nandi

10. Rewati Raman Ujjwal