BSc(Ag)Hons, Bidhan Chandra Krishi Viswa Vidyalaya, West Bengal, India (Aug 1991- Dec 1995)
MSc in Biotechnology, Jawaharlal Nehru University, New Delhi, India (1st Aug 1996- Jul 1998)
Research fellow at National Centre for Biological Science, Bangalore, India (1st Aug 1998-15th Jan 2002)
Research fellow at Dept of Biochemistry, Indian Institute of Science, Bangalore, India (1st Feb 2002-31st May 2002)
PhD thesis work at the Dept of Biochemistry, Freie University of Berlin, Germany (1st Jun 2002-31st Dec 2005)
Post doctoral fellow at Max Planck Institute for Molecular Genetics, Berlin, Germany (1st Jan 2006-15th July 2009)
- Indian Society for Cell Biology (AICB) (Life member)
- Society for Biological Chemistry India (SBCI) (Life member)
- Indian Society for the Study of Reproduction and Fertility (ISSRF) (Life member)
- Society of Biotechnologists (India) (Life member)
- International Society for Neurochemistry (ISN) (Seasonal member)
- European society for Neurochemistry (ESN) (Seasonal member)
- International Association for Study of Pain (IASP) (Seasonal member)
- Special Interest Group on Neuropathic Pain (NeuPSIG) (Seasonal member)
- The FEBS Journal
- Proteomic Insight
- Cell Health and Cytoskeleton
- Cell biochemistry and Biophysics
- Cell biology International
- Cell Health and Cytoskeleton
- Journal of Molecular Medicine
- Journal of neurochemistry
- Journal of cell science
- Neurochemistry International
- The FEBS journal
- The Neuroscience Letters
- Trends in neuroscience
- Importance of the crosstalk between TRP channels and cytoskeleton in chronification of Pain: Recent results suggest that different cytoskeleton as well as multiple receptors recognizing several noxious stimuli contribute to the pain signaling. Several key molecular factors which are involved in acute and chronic pain have been identified. Among those, TRPV receptors (TRPV1-6) are important as these receptors act as non-selective cation channels and recognize several stimuli, and integrate extracellular as well as intracellular signaling events. Interestingly, involvement of microtubule cytoskeleton in the chronification of pain has been speculated for a long time. We are the first one to demonstrate the physical interaction between TRPV channels with microtubule cytoskeleton and functional relevence of such cross-talk in the context of different cellular functions.
- Importance of TRP channels as a sub-membraneous signalling scaffold: Taxol®, a microtubule stabilizer, often used as a chemotherapeutic drug in the treatment of cancer and AIDS is known to induce severe and chronic neuropathic pain. However, the exact molecular mechanisms of Taxol®-induced strong chronic pain is currently not known. TRP ion channels act as a molecular scaffold at the sub-membranous region, interact with different cellular components including microtubule cytoskeleton and contribute to different pain signaling. Among all channels, we are interested to elucidate the role of thermo-sensitive ion channels, namely TRPV channels (TRPV1-6), TRPM8 and TRPA1 in the context of Calcium ion-dependent as well as Calcium ion-independent signaling and further cytoskeletal reorganization. Such understanding has importance in the context to chemotherapy-induced chronifiction of pain.
- Regulation of vesicular recycling by TRP channels: Receptor-mediated uptake, exocytosis, endocytosis, vesicle trafficking and recycling are complex cellular events which control several cellular functions. For neurons, such functions in turn control synaptic functions, release and/or uptake of specific neurotransmitters. Regulation of vesicular recycling also regulates the neuronal structures and connectivity. Interestingly, different thermosensitive TRP channels regulate these aspects in a very specific and unique manner. Using high-end imaging techniques we characterize these TRP-mediated vesicular recycling and membrane organization. Such understandings have broad importance in different neuronal as well as non-neuronal systems and have immense implications to dissect pathophysiological disorder at the cellular and molecular levels.
- TRPV-mediated channelopathy: Rare yet naturally occurring mutations in TRPV channels are known to induce several critical pathophysiological disorders due to altered channel function, regulation and/or distribution. For example, mutations in TRPV4 lead to development of CMT2 disease and other mascular dystrophies. Similarly, mutations in TRPV3 lead to “Olmsted Syndrome”. Such mutations alter channels' structure-function relationship and affect cellular functions largely. We aim to understand the molecular and cellular mechanisms that go wrong in such cases.
- Imporatnce of TRP channels in reproduction: TRP channels are present in several parts of the reproductive tissues including mature male gametes. In sperm cells, thermosensitive TRP channels seem to play diverse and complex functions such as thermosensation, Calcium signaling, capacitation, acrosomal reaction, regulation of sperm motility and fertility. We explore these functions in details. Such understandings will have both clinical and commercial importance in future as well.
- TRP channels in immune function: Immune activation is a temperature dependent event and also needs massive Calcium influx. Indeed, so far several reports have suggested that TRP channels are present in the immune cells where diverse immune functions are regulated by this group of proteins. We investigate the importance of thermosensitive TRP ion channels in mammalian immune systems.
- Molecular evolution of TRP channels: Genes coding for TRP channels are present in fungus to human (but so far have not been identified in plants). In all these species, TRP channels mainly act as a set of molecular tools required for different “sensory” functions. Over millions of years, such functions in turn play crucial role in the adaptation, ecological niche formation, speciation and also in evolution. Analyzing the sequences of TRP channels from different species provides useful information regarding the selection pressure and the molecular evolution of these channels. Such in silico analysis helped us to identify certain hidden motifs and characterize such motifs in details, which provides useful information regarding the molecular mechanism of these channels per se.
Cell biology of TRP ion channels: Implications in pain and other pathophysiology
a. Qualified for the National Scholarship for both Secondary and Higher Secondary examination (Govt. of India).
b. Obtained scholarship from Bidhan Chandra Krishi Viswa Vidyalaya from 1991 to 1995.
c. Obtained fellowship from Govt. of West Bengal, India from Feb 1996- July 1996 for Farm training.
d. Stood 1st in the All India Entrance Examination for Agricultural Biotechnology during 1996.
e. Obtained scholarship from Dept. of Biotechnology, Govt. of India, from 1996 Aug to 1998 April.
f. Qualified CSIR-NET (National Eligibility Test, Council of Scientific & Industrial Research, India) during 1997 Dec.
g. Obtained Research Fellowship from Tata Institute of Fundamental Research, Bangalore from Aug 1998 to Jan 2002.
h. Obtained Research Fellowship from Indian Institute of Science, Bangalore, India. 1st Feb 2002 to 30th May 2002.
i. Obtained fellowship BAT2a/2 from SFB515, Germany since 1st June 2002 -31st Dec 2005.
j. Obtained Distinction (“Summa cum laude”) in PhD program, Freie Universitat Berlin, March 2006.
k. Obtained fellowship from Max Planck Institute for Molecular Genetics since 1st Jan 2006-July 2009
l. Obtained best poster award from German society for Biochemistry and Molecular Biology (GBM) at fall meeting, 2007 Hamburg, Germany.
m. Won a bursary award from International Association for the Study of Pain (IASP) to attend the Third International Congress on Neuropathic Pain, May 27-30, 2010, Athens, Greece.
n. Obtained “Letter of appreciation” for teaching performance from NISER.
o. Selected as a member of “Board of academics”, Utkal University. Bhubaneswar, India (Since 2010-till now)
p. Convener of XXXV All India Cell Biology Conference and symposia on membrane dynamics and disease, 2011
q. “Member, Board of studies”, Ravenshaw University, Cuttack (Since 2011-till now)
r. Elected as an executive member (2013-2015) of All India Society for Cell Biology
s. Served as a “Resource person” for UGC refreshers course at Sambalpur University, 2014
Membership of professional and scientific organization:
Other scientific activities and organizational work:
a) Local organizing committee member of Regional Biochemical Symposium on 3rd Sept 2011, NISER, Bhubaneswar
b) Convener of XXXV All India Cell Biology conference and symposium on “Membrane Dynamics and disease”, 16-18th Dec 2011, at NISER, Bhubaneswar, India
c) Local organizing committee member of Indian Immunology Society - Odisha Chapter, Aug 11, 2012, NISER, Bhubaneswar
Editorial Job for peer reviewed Journals:
Reviewing Job (15 Journals):
1. Goswami C., Dreger M., Jahnel R., Bogen O., Gillen C. and Hucho F. (2004) Identification and characterization of a Ca2+-sensitive interaction of the vanilloid receptor TRPV1 with tubulin. J Neurochem. 91, 1092-103. (IF in 2004: 5.232; Total citation in Jan 2014: 56)
2. Goswami C., Dreger M., Otto H., Schwappach B. and Hucho F. (2006) Rapid disassembly of dynamic microtubules upon activation of the capsaicin receptor TRPV1. J Neurochem. 96, 254-266.
(IF in 2006: 4.9; Total citation in Jan 2014: 44)
3.* Goswami C., Schmidt H. and Hucho F. (2007) Regulation of growth cone morphology and movement by TRPV1 activation. FEBS journal. 274, 760-72. (Cover page)
(IF in 2013: 4.25; Total citation in Jan 2014: 39)
4. Goswami C., Hucho T. and Hucho F. (2007) Identification and characterisation of novel tubulin-binding motifs located within the C-terminus of TRPV1. J Neurochem. 101, 250-262.
(IF in 2007: 4.8; Total citation in Jan 2014: 25)
5. M. Motazacker, B. Rost, T. Hucho, M. Garshasbi, K. Kahrizi, R. Ullmann, S. Abedini, S. Nieh, S. Amini, C. Goswami, A. Tzschach, L. Jensen, D. Schmitz, H.H. Ropers, H. Najmabadi, A.W. Kuss A (2007) Defect in the Ionotropic Glutamate Receptor 6 Gene (GRIK2) is Associated with Autosomal Recessive Mental Retardation. American Journal of Human Genetics 81, 792-8. (IF in 2009: 12.303; Total citation in Jan 2014: 84)
6. Goswami C. and Hucho T. (2007) TRPV1 expression-dependent initiation and regulation of filopodial. J Neurochem. 103, 1319-33. (IF in 2007: 4.8; Total citation in Jan 2014: 26)
7. Goswami C. and Hucho T. (2008) Invited review series: Novel aspects of the submembraneous microtubule cytoskeleton. FEBS journal. 275, 4653. (Invited review) (IF in 2013: 4.25; Total citation in Jan 2014: 4)
8.* Goswami C. and Hucho T. (2008) Submembraneous microtubule cytoskeleton: Biochemical and functional interplay of TRP channels with the cytoskeleton. FEBS journal. 275, 4684-4699. (Invited review)
(IF in 2013: 4.25, Total citation in Jan 2014: 14)
9. Kuhn J, Dina Y, Goswami C., Suckow V, Levine J, Tim Hucho. (2008) GPR30 Estrogen Receptor Agonists Induce Mechanical Hyperalgesia in the Rat. European journal of neuroscience. 27, 1700-9.
(IF in 2010: 3.658, Total citation in Jan 2014: 56)
10. Goswami C, Islam MS. (2010) Transient Receptor Potential channels: What's happening? Reflections in the wake of the 2009 TRP Meeting, Karolinska Institutet, Stockholm. Channels (Austin). 4, 124-35 (IF in 2011: 2.14; Total citation in Jan 2014: 4)
11. Goswami C, Rademacher N, Smalla KH, Kalscheuer V, Ropers HH, Gundelfinger ED, Hucho T. (2010) TRPV1 acts as a synaptic protein and regulates vesicle recycling. J Cell Sci. 123, 2045-57
(IF in 2010: 6.29; Total citation in Jan 2014: 13)
12. Goswami C, Kuhn J, Heppenstall PA, Hucho T. (2010) Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLOS one. 5 e11654
(IF in 2010: 4.411; Total citation in Jan 2014: 37)
13. Goswami C, Goswami L. (2010) Filamentous microtubules in the neuronal spinous process and the role of microtubule regulatory drugs in neuropathic pain. Neurochem Int. 57, 497-503
(IF in 2010: 3.601; Total citation in Jan 2014: 4)
14.* Verma P, Kumar A, Goswami C. (2010) TRPV4-mediated channelopathies. Channels (Austin). 4, 319-328 (IF in 2011: 2.14; Total citation in Jan 2014: 19)
15. Goswami C (2010) Structural and functional regulation of growth cone, filopodia and synaptic sites by TRPV1. Journal of Communicative & Integrative Biology 3, 614-618
(IF in 2011: 1.66; Total citation in Jan 2014: 4)
16. Goswami C, Kuhn J, Dina OA, Fernandez-Ballester G, Levine JD, Ferrer-Montiel A, Hucho T. (2011) Estrogen destabilizes microtubules through an ion-conductivity independent TRPV1 pathway. J Neurochem. 117, 995-1008 (IF in 2011: 4.364; Total citation in Jan 2014: 15)
17. *Majhi R, Sardar P, Goswami L, Goswami C. (2011) Right time - right location - right move: TRPs find motors for common functions. Channels (Austin). 5. 375-381 (IF in 2011: 2.14; Total citation in Jan 2014:3)
18. Sardar P, Kumar A, Bhandari A, Goswami C. (2012) Conservation of tubulin-binding sequences in TRPV1 throughout evolution. PlosOne 7, e31448 (IF in 2012: 4.092; Total citation in Jan 2014: 4)
19. Kumar A, Bhandari A, Sinha R, Sardar P, Sushma, Goyal P, Goswami C. and Grapputo A. (2012) Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions.PlosOne 7, e39399 (IF in 2012: 4.092; Total citation in Jan 2014: 1)
20. Goswami C (2012) TRPV1-tubulin complex: involvement of membrane tubulin in the regulation of chemotherapy induced peripheral neuropathy. J Neurochem. 123, 1-13
(IF in 2012: 4.061; Total citation in Jan 2014: 5)
21. *Goswami C (2012) TRPs-mediated cytoskeletal reorganization: implications for disease and drug development. Book chapter (Springer) ISBN: 978-1-62703-076-2. Page 13-39
(IF in 2013: X; Total citation in Jan 2014: 1)
22. Kumar A, Goswami L, Goswami C (2013) Importance of TRP channels in pain: implications for stress. Frontiers in Bioscience. (Schol Ed) 5, 19-38 (IF in 2013: 3.52; Citation in Feb 2013: 0)
23. Kumar A, Majhi R, Yadav M, Szallasi A, Goswami C. (2013) TRPV1 activators (“vanilloids”) as neurotoxins. Book chapter (Springer) (In press) (IF in 2013: X; Citation in Jan 2014: 0)
24. *Majhi R K, Kumar A, Yadav M, Swain N, Kumari S, Saha A, Pradhan A, Goswami L, Saha S, Samanta L, Maity A, Nayak TK, Chattopadhyay S, Rajakuberan C, Kumar A, Goswami C. (2013) Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility. Channels 7, 1-10 (IF when published: 2.159; Citation in Jan 2014: 0)
25. Kumar A, Bhandari A, Sarde SJ, Goswami C. (2013) Sequence, phylogenetic and variant analyses of Antithrombin III. Biochemical and Biophysical Research Communications. 440, 714-24
(IF when published: 2.5; Citation in Jan 2014: 0)
26. Sanyasi S, Kumar A, Goswami C, Bandyopadhyay A, Goswami L (2014) A carboxy methyl tamarind polysaccharide matrix for adhesion and growth of osteoclast-precursor cells. Carbohydrate Polymers, 101, 1033-1042 (IF when published: 4; Citation in Jan 2014: 0)
27. Pati R, Mehta R, Mohanty S, Padhi A, Sengupta M, Baskarlingam V, Goswami C, Sonawane A. (2014) Topical application of zinc oxide nanoparticles reduce bacterial skin infection in mice and exhibit antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages. Nanomedicine S1549-9634(14)00114-2. (IF in 2013: 7.647; Citation in Jan 2014: 0)
28. Pradhan N, Pratheek BM, Garai A, Kumar A, Meena VS, Ghosh S, Singh S, Kumari S, Chandrashekar TK, Goswami C, Chattopadhyay S, Kar S, Maiti PK. (2014) Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells. Cell biology international 38, 1118-31.
(IF when published: 1.64 Citation in Feb 2014: X)
29. Kumar A, Bhandari A, Sarde SJ, Goswami C. (2014) Sequence, synteny, phylogeny and variants analyses of heparin cofactor II. Immunobiology 219, 713-28.
(IF when published: 2.371 Citation in Feb 2013)
30. Kumar A, Bhandari A, Sarde SJ and Goswami C. (2014) Molecular phylogeny of C1 inhibitor depicts two immunoglobulin-like domains fusion in fishes and ray-finned fishes specific intron insertion after separation from zebrafish.Biochemical and Biophysical Research Communications. 450, 219-26.
31. Kumar A, Sahu SK, Mohanty S, Chakrabarti S, Maji S, Reddy RR, Jha AK, Goswami C, Kundu CN, Rajasubramaniam S, Verma SC, Choudhuri T. (2014) Kaposi Sarcoma Herpes Virus Latency Associated Nuclear Antigen Protein Release the G2/M Cell Cycle Blocks by Modulating ATM/ATR Mediated Checkpoint Pathway. PLoS One. 9(6):e100228.
32. Kumar A, Kumari S, Majhi RK, Swain N, Yadav M, Goswami C. (2014) Regulation of TRP channels by steroids: Implications in physiology and diseases. General and Comparative Endocrinology S0016-6480(14)00398-0.
33. Rath S, Das L, Kokate S.B, Chattopadhyay S, Goswami C, Chattopadhyay R, Crowe S.E., Bhattacharyya A (2014) Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells. FASEB J 29, 796-806.
34. Kumar A, Bhandari A, Goswami C (2014) Surveying genetic variants and molecular phylogeny of cerebral cavernous malformation gene, CCM3/PDCD10. Biochemical and Biophysical Research Communications 455, 98-106.
35. Kumari S, Kumar A, Sardar P, Yadav M, Majhi RK, Kumar A, Goswami C (2015) Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4. Biochemical and Biophysical Research Communications 456, 312-9.
36. Majhi RK, Sahoo SS, Yadav M, Chattopadhyay S, Goswami C. (2015) Functional Expression of TRPV Channels in T cells And Their Implications in Immune Regulation. The FEBS Journal. 282, 2661-81.
37. Majhi RK, Saha S, Kumar A, Ghosh A, Swain N, Goswami L, Mohapatra PP, Maity A, Sahoo V, Kumar A, Goswami C. (2015) Expression of temperature-sensitive ion channel TRPM8 in sperm cells correlates with vertebrate evolution.PeerJ. 3:e1310.
38. Majhi RK, Kumar A, Yadav M, Kumar P, Maity A, Giri SC, Goswami C. (2016) Light and electron microscopic study of mature spermatozoa from white pekin duck (Anas platyrhynchos): An ultra-structural and molecular analysis.Andrology 4, 232-44
39. Gayatri Mohanty, Nirlipta Swain, Chandan Goswami, Sujata Kar, Luna Samanta (2016) Histone retention, protein carbonylation and lipid peroxidation in spermatozoa: Possible role in recurrent pregnancy loss. Systems Biology in Reproductive Medicine (Accepted)
40. Das Jugal Kishore; Mahapatra Rajanikanta, Patro Subhranshu; Goswami Chandan; Suar Mrutyunjay (2016) Lactobacillus acidophilus binds to MUC3 component of cultured intestinal epithelial cells with highest affinity. FEMS Microbiology Letters (Accepted)
41. Arijit Ghosh, Navneet Kaur, Abhishek Kumar, Chandan Goswami. (2016) Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data. Channels (Accepted)
42. Ashutosh Kumar; Rakesh K Majhi; Nirlipta Swain; Sunil C Giri; Sujata Kar; Luna Samanta; Chandan Goswami (2016) TRPV4 is endogenously expressed in vertebrate spermatozoa and regulates intracellular calcium in human sperm. BBRC. (Accepted)